Endocrine Abstracts

Background: Guidelines in healthcare shall be evidence-based, satisfy patients’ needs and improve patients’ outcomes. We aimed to estimate incremental costs after the introduction of a national guideline for Graves’ disease in Sweden adding the Graves’ Recurrent Events After Therapy (GREAT) score with genetic determinants to predict recurrence, a thyroid nurse, calcium-D-vitamin treatment preoperatively, and thyroid stimulating immunoglobulins.<p class=...

Background: Mental fatigue, depression and anxiety are common in Graves’ disease (GD). Our aims were to assess the relationship between these variables among GD patients both in the hyperthyroid phase and after treatment. The pathogenic mechanisms involved in these symptoms are unknown and so is if previous psychiatric disease influences these symptoms.Methods: This was a longitudinal case control study in Göteborg, Sweden, on 65 women with new...

Background: Graves orbitopathy (GO) is the most frequent and feared complication of Graves’ disease. In moderate-severe cases, intravenous (iv) glucocorticoids (GC) is the first-line treatment while Rituximab (RTX) is recommended as second-line treatment in patients non-responsive to GC. But data is scarce and contradictory.Objective: To investigate if patients with GO and poor response to iv GC benefit from a switch to RTX early in the treatment co...

Introduction: In the UK, most adult patients with growth hormone deficiency (GHD) continue with growth hormone (GH) treatment indefinitely, even when they do not report any benefits from treatment. To date, the optimal duration of GH treatment in adults has not been established. We conducted a survey of UK endocrine clinicians between 01/06/2022 and 31/08/2022 to understand current practices regarding GH treatment discontinuation in adults with GHD.<p clas...

Background: A diagnosis Silver–Russell Syndrome (SRS) is important for early institution of appropriate management, access to therapy and reduces the burden of diagnostic uncertainty. SRS is molecularly heterogeneous and 11p15 LOM/upd(7)mat account for ~60% cases. Monogenic causes include variants in HMGA2, CDKN1C, IGF-2, PLAG1 and contribute to 5% cases. Clinical SRS diagnosis requires the fulfilment of ≥4/6 Netchine–Harbison Clinical Scoring ...

Background: Pituitary adenomas are the most prevalent tumours in the sellar region and can either be functioning, with autonomous pituitary hormone secretion, or non-functioning. Clinically evident adenomas occur in 1 in 1,100 in the general population. Pituitary adenomas have traditionally been subdivided into microadenomas (<10 mm) or macroadenomas (≥ 10 mm), with macroadenomas comprising 48% of clinically relevant adenomas. Non-functioning pituita...

Objective: Combined oral contraceptive pills (COCP), primarily used for contraception; are also indicated in other conditions including polycystic ovary syndrome (PCOS). Evidence on the prevalence and patterns of COCP use in PCOS compared to those without the condition are unknown, and studies in unselected populations, especially longitudinally, are very limited. The aim of this study was to examine prevalence and patterns of COCP use in women with PCOS, compared to the backg...

Background: Primary adrenal insufficiency (PAI) predisposes patients to infections, which can precipitate life-threatening adrenal crises. PAI patients are thought to be particularly vulnerable to COVID-19; however, little is known about its true impact on this group.Aim: To assess morbidity and health promotion attitudes during the COVID-19 pandemic amongst a large cohort of PAI patients.Methods: In May 2020 COVID-19 information, ...

Context: Turner syndrome (TS) is associated with short stature, delayed puberty, primary ovarian insufficiency, infertility, and other features. The majority of girls with TS require pubertal induction and life-long oestrogen replacement therapy. There is paucity of data in adult TS on the efficacy of pubertal induction, such as breast satisfaction. Patient-related outcome measures (PROMs) assess the quality of care and treatment from the patient’s perspective. We have em...

Introduction: MODY 5 is a rare form of autosomal dominant monogenic diabetes with a broad phenotypical spectrum that occurs with pancreatic and extra-pancreatic clinical manifestations, such as: malformation and dysfunction of the pancreas, nephrourologic anomalies, impaired renal function, hepatopathy and neurocognitive defects. It is caused by a mutation of the gene encoding hepatocyte nuclear transcription factor 1 beta (HNF1β).Case 1: M...